Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
antirrhinum_hispanicum_GWHPBJVR000433	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR000433
antirrhinum_hispanicum_GWHPBJVR000546	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR000546
antirrhinum_hispanicum_GWHPBJVR000553	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR000553
antirrhinum_hispanicum_GWHPBJVR001278	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR001278
antirrhinum_hispanicum_GWHPBJVR001471	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR001471
antirrhinum_hispanicum_GWHPBJVR002373	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR002373
antirrhinum_hispanicum_GWHPBJVR002996	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR002996
antirrhinum_hispanicum_GWHPBJVR002997	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR002997
antirrhinum_hispanicum_GWHPBJVR002998	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR002998
antirrhinum_hispanicum_GWHPBJVR002999	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR002999
antirrhinum_hispanicum_GWHPBJVR003120	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003120
antirrhinum_hispanicum_GWHPBJVR003121	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003121
antirrhinum_hispanicum_GWHPBJVR003125	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003125
antirrhinum_hispanicum_GWHPBJVR003295	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003295
antirrhinum_hispanicum_GWHPBJVR003296	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003296
antirrhinum_hispanicum_GWHPBJVR003298	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003298
antirrhinum_hispanicum_GWHPBJVR003300	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003300
antirrhinum_hispanicum_GWHPBJVR003926	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR003926
antirrhinum_hispanicum_GWHPBJVR004100	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR004100
antirrhinum_hispanicum_GWHPBJVR004101	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR004101
antirrhinum_hispanicum_GWHPBJVR004121	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR004121
antirrhinum_hispanicum_GWHPBJVR004605	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR004605
antirrhinum_hispanicum_GWHPBJVR005292	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR005292
antirrhinum_hispanicum_GWHPBJVR006450	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR006450
antirrhinum_hispanicum_GWHPBJVR006814	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR006814
antirrhinum_hispanicum_GWHPBJVR006815	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR006815
antirrhinum_hispanicum_GWHPBJVR007203	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR007203
antirrhinum_hispanicum_GWHPBJVR007205	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR007205
antirrhinum_hispanicum_GWHPBJVR007211	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR007211
antirrhinum_hispanicum_GWHPBJVR007578	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR007578