Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
antirrhinum_hispanicum_GWHPBJVR007815	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR007815
antirrhinum_hispanicum_GWHPBJVR007816	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR007816
antirrhinum_hispanicum_GWHPBJVR007889	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR007889
antirrhinum_hispanicum_GWHPBJVR008063	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR008063
antirrhinum_hispanicum_GWHPBJVR008584	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR008584
antirrhinum_hispanicum_GWHPBJVR008585	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR008585
antirrhinum_hispanicum_GWHPBJVR009266	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR009266
antirrhinum_hispanicum_GWHPBJVR009682	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR009682
antirrhinum_hispanicum_GWHPBJVR009736	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR009736
antirrhinum_hispanicum_GWHPBJVR011122	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR011122
antirrhinum_hispanicum_GWHPBJVR011384	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR011384
antirrhinum_hispanicum_GWHPBJVR011940	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR011940
antirrhinum_hispanicum_GWHPBJVR011991	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR011991
antirrhinum_hispanicum_GWHPBJVR011992	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR011992
antirrhinum_hispanicum_GWHPBJVR013210	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013210
antirrhinum_hispanicum_GWHPBJVR013568	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013568
antirrhinum_hispanicum_GWHPBJVR013569	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013569
antirrhinum_hispanicum_GWHPBJVR013690	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013690
antirrhinum_hispanicum_GWHPBJVR013706	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013706
antirrhinum_hispanicum_GWHPBJVR013710	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013710
antirrhinum_hispanicum_GWHPBJVR013712	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013712
antirrhinum_hispanicum_GWHPBJVR013715	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013715
antirrhinum_hispanicum_GWHPBJVR013886	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR013886
antirrhinum_hispanicum_GWHPBJVR014762	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR014762
antirrhinum_hispanicum_GWHPBJVR014891	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR014891
antirrhinum_hispanicum_GWHPBJVR014893	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR014893
antirrhinum_hispanicum_GWHPBJVR015937	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR015937
antirrhinum_hispanicum_GWHPBJVR015971	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR015971
antirrhinum_hispanicum_GWHPBJVR016366	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR016366
antirrhinum_hispanicum_GWHPBJVR017677	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR017677