Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
antirrhinum_hispanicum_GWHPBJVR017792	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR017792
antirrhinum_hispanicum_GWHPBJVR019382	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR019382
antirrhinum_hispanicum_GWHPBJVR019383	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR019383
antirrhinum_hispanicum_GWHPBJVR020536	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR020536
antirrhinum_hispanicum_GWHPBJVR020985	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR020985
antirrhinum_hispanicum_GWHPBJVR020986	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR020986
antirrhinum_hispanicum_GWHPBJVR022038	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR022038
antirrhinum_hispanicum_GWHPBJVR022039	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR022039
antirrhinum_hispanicum_GWHPBJVR024308	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024308
antirrhinum_hispanicum_GWHPBJVR024334	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024334
antirrhinum_hispanicum_GWHPBJVR024629	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024629
antirrhinum_hispanicum_GWHPBJVR024786	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024786
antirrhinum_hispanicum_GWHPBJVR024789	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024789
antirrhinum_hispanicum_GWHPBJVR024790	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024790
antirrhinum_hispanicum_GWHPBJVR024791	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024791
antirrhinum_hispanicum_GWHPBJVR024792	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024792
antirrhinum_hispanicum_GWHPBJVR024793	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR024793
antirrhinum_hispanicum_GWHPBJVR025084	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR025084
antirrhinum_hispanicum_GWHPBJVR025221	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR025221
antirrhinum_hispanicum_GWHPBJVR025226	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR025226
antirrhinum_hispanicum_GWHPBJVR025227	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR025227
antirrhinum_hispanicum_GWHPBJVR025232	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR025232
antirrhinum_hispanicum_GWHPBJVR026092	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR026092
antirrhinum_hispanicum_GWHPBJVR026093	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR026093
antirrhinum_hispanicum_GWHPBJVR026095	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR026095
antirrhinum_hispanicum_GWHPBJVR027301	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR027301
antirrhinum_hispanicum_GWHPBJVR028710	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR028710
antirrhinum_hispanicum_GWHPBJVR029852	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR029852
antirrhinum_hispanicum_GWHPBJVR029854	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR029854
antirrhinum_hispanicum_GWHPBJVR032048	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR032048