Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
antirrhinum_hispanicum_GWHPBJVR032191	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR032191
antirrhinum_hispanicum_GWHPBJVR032231	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR032231
antirrhinum_hispanicum_GWHPBJVR033038	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR033038
antirrhinum_hispanicum_GWHPBJVR033039	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR033039
antirrhinum_hispanicum_GWHPBJVR033254	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR033254
antirrhinum_hispanicum_GWHPBJVR033980	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR033980
antirrhinum_hispanicum_GWHPBJVR034437	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR034437
antirrhinum_hispanicum_GWHPBJVR034594	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR034594
antirrhinum_hispanicum_GWHPBJVR035053	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR035053
antirrhinum_hispanicum_GWHPBJVR035129	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR035129
antirrhinum_hispanicum_GWHPBJVR035401	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR035401
antirrhinum_hispanicum_GWHPBJVR036011	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR036011
antirrhinum_hispanicum_GWHPBJVR036273	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR036273
antirrhinum_hispanicum_GWHPBJVR036275	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR036275
antirrhinum_hispanicum_GWHPBJVR036338	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR036338
antirrhinum_hispanicum_GWHPBJVR036666	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR036666
antirrhinum_hispanicum_GWHPBJVR036736	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR036736
antirrhinum_hispanicum_GWHPBJVR036808	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR036808
antirrhinum_hispanicum_GWHPBJVR037969	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR037969
antirrhinum_hispanicum_GWHPBJVR039139	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR039139
antirrhinum_hispanicum_GWHPBJVR040316	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR040316
antirrhinum_hispanicum_GWHPBJVR040331	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR040331
antirrhinum_hispanicum_GWHPBJVR040344	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR040344
antirrhinum_hispanicum_GWHPBJVR040459	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR040459
antirrhinum_hispanicum_GWHPBJVR040546	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR040546
antirrhinum_hispanicum_GWHPBJVR040753	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR040753
antirrhinum_hispanicum_GWHPBJVR041013	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR041013
antirrhinum_hispanicum_GWHPBJVR041019	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR041019
antirrhinum_hispanicum_GWHPBJVR041048	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR041048
antirrhinum_hispanicum_GWHPBJVR041049	antirrhinum_hispanicum	antirrhinum_hispanicum_GWHPBJVR041049