Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
arabidopsis_arenosa_CAE5976777.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE5976777.1
arabidopsis_arenosa_CAE5978199.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE5978199.1
arabidopsis_arenosa_CAE5978551.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE5978551.1
arabidopsis_arenosa_CAE5980325.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE5980325.1
arabidopsis_arenosa_CAE5993551.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE5993551.1
arabidopsis_arenosa_CAE6003241.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6003241.1
arabidopsis_arenosa_CAE6003437.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6003437.1
arabidopsis_arenosa_CAE6003460.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6003460.1
arabidopsis_arenosa_CAE6003480.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6003480.1
arabidopsis_arenosa_CAE6003506.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6003506.1
arabidopsis_arenosa_CAE6005105.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6005105.1
arabidopsis_arenosa_CAE6005373.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6005373.1
arabidopsis_arenosa_CAE6005943.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6005943.1
arabidopsis_arenosa_CAE6019672.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6019672.1
arabidopsis_arenosa_CAE6027366.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6027366.1
arabidopsis_arenosa_CAE6036146.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6036146.1
arabidopsis_arenosa_CAE6047911.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6047911.1
arabidopsis_arenosa_CAE6066811.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6066811.1
arabidopsis_arenosa_CAE6067008.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6067008.1
arabidopsis_arenosa_CAE6072476.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6072476.1
arabidopsis_arenosa_CAE6072624.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6072624.1
arabidopsis_arenosa_CAE6072924.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6072924.1
arabidopsis_arenosa_CAE6073345.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6073345.1
arabidopsis_arenosa_CAE6075166.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6075166.1
arabidopsis_arenosa_CAE6075185.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6075185.1
arabidopsis_arenosa_CAE6075929.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6075929.1
arabidopsis_arenosa_CAE6076336.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6076336.1
arabidopsis_arenosa_CAE6076810.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6076810.1
arabidopsis_arenosa_CAE6078532.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6078532.1
arabidopsis_arenosa_CAE6081848.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6081848.1