Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
arabidopsis_arenosa_CAE6082203.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6082203.1
arabidopsis_arenosa_CAE6091193.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6091193.1
arabidopsis_arenosa_CAE6092870.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6092870.1
arabidopsis_arenosa_CAE6099799.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6099799.1
arabidopsis_arenosa_CAE6104886.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6104886.1
arabidopsis_arenosa_CAE6105852.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6105852.1
arabidopsis_arenosa_CAE6115889.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6115889.1
arabidopsis_arenosa_CAE6116199.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6116199.1
arabidopsis_arenosa_CAE6117793.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6117793.1
arabidopsis_arenosa_CAE6117805.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6117805.1
arabidopsis_arenosa_CAE6117831.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6117831.1
arabidopsis_arenosa_CAE6117855.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6117855.1
arabidopsis_arenosa_CAE6125013.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6125013.1
arabidopsis_arenosa_CAE6125058.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6125058.1
arabidopsis_arenosa_CAE6125083.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6125083.1
arabidopsis_arenosa_CAE6125189.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6125189.1
arabidopsis_arenosa_CAE6125212.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6125212.1
arabidopsis_arenosa_CAE6134472.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6134472.1
arabidopsis_arenosa_CAE6139598.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6139598.1
arabidopsis_arenosa_CAE6153793.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6153793.1
arabidopsis_arenosa_CAE6159390.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6159390.1
arabidopsis_arenosa_CAE6159414.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6159414.1
arabidopsis_arenosa_CAE6167550.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6167550.1
arabidopsis_arenosa_CAE6182118.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6182118.1
arabidopsis_arenosa_CAE6182143.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6182143.1
arabidopsis_arenosa_CAE6192257.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6192257.1
arabidopsis_arenosa_CAE6192272.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6192272.1
arabidopsis_arenosa_CAE6194753.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6194753.1
arabidopsis_arenosa_CAE6195165.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6195165.1
arabidopsis_arenosa_CAE6195644.1	arabidopsis_arenosa	arabidopsis_arenosa_CAE6195644.1