Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_hemsleyana_GWHPCBQA021316	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA021316
actinidia_hemsleyana_GWHPCBQA022332	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA022332
actinidia_hemsleyana_GWHPCBQA022333	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA022333
actinidia_hemsleyana_GWHPCBQA022334	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA022334
actinidia_hemsleyana_GWHPCBQA022996	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA022996
actinidia_hemsleyana_GWHPCBQA023211	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA023211
actinidia_hemsleyana_GWHPCBQA023574	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA023574
actinidia_hemsleyana_GWHPCBQA023575	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA023575
actinidia_hemsleyana_GWHPCBQA023642	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA023642
actinidia_hemsleyana_GWHPCBQA023713	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA023713
actinidia_hemsleyana_GWHPCBQA023900	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA023900
actinidia_hemsleyana_GWHPCBQA023901	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA023901
actinidia_hemsleyana_GWHPCBQA024934	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA024934
actinidia_hemsleyana_GWHPCBQA025555	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA025555
actinidia_hemsleyana_GWHPCBQA026092	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026092
actinidia_hemsleyana_GWHPCBQA026099	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026099
actinidia_hemsleyana_GWHPCBQA026100	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026100
actinidia_hemsleyana_GWHPCBQA026101	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026101
actinidia_hemsleyana_GWHPCBQA026104	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026104
actinidia_hemsleyana_GWHPCBQA026105	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026105
actinidia_hemsleyana_GWHPCBQA026106	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026106
actinidia_hemsleyana_GWHPCBQA026712	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026712
actinidia_hemsleyana_GWHPCBQA026714	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026714
actinidia_hemsleyana_GWHPCBQA026715	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA026715
actinidia_hemsleyana_GWHPCBQA027468	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA027468
actinidia_hemsleyana_GWHPCBQA027470	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA027470
actinidia_hemsleyana_GWHPCBQA027471	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA027471
actinidia_hemsleyana_GWHPCBQA027884	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA027884
actinidia_hemsleyana_GWHPCBQA027885	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA027885
actinidia_hemsleyana_GWHPCBQA028590	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA028590