Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_hemsleyana_GWHPCBQA028722	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA028722
actinidia_hemsleyana_GWHPCBQA029134	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA029134
actinidia_hemsleyana_GWHPCBQA029135	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA029135
actinidia_hemsleyana_GWHPCBQA029448	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA029448
actinidia_hemsleyana_GWHPCBQA030264	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA030264
actinidia_hemsleyana_GWHPCBQA031292	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA031292
actinidia_hemsleyana_GWHPCBQA031294	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA031294
actinidia_hemsleyana_GWHPCBQA031295	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA031295
actinidia_hemsleyana_GWHPCBQA031439	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA031439
actinidia_hemsleyana_GWHPCBQA031845	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA031845
actinidia_hemsleyana_GWHPCBQA031846	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA031846
actinidia_hemsleyana_GWHPCBQA031921	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA031921
actinidia_hemsleyana_GWHPCBQA032034	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA032034
actinidia_hemsleyana_GWHPCBQA032575	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA032575
actinidia_hemsleyana_GWHPCBQA032990	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA032990
actinidia_hemsleyana_GWHPCBQA032991	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA032991
actinidia_hemsleyana_GWHPCBQA033607	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA033607
actinidia_hemsleyana_GWHPCBQA034129	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA034129
actinidia_hemsleyana_GWHPCBQA034607	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA034607
actinidia_hemsleyana_GWHPCBQA035056	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035056
actinidia_hemsleyana_GWHPCBQA035057	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035057
actinidia_hemsleyana_GWHPCBQA035555	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035555
actinidia_hemsleyana_GWHPCBQA035577	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035577
actinidia_hemsleyana_GWHPCBQA035762	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035762
actinidia_hemsleyana_GWHPCBQA035764	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035764
actinidia_hemsleyana_GWHPCBQA035765	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035765
actinidia_hemsleyana_GWHPCBQA035931	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA035931
actinidia_hemsleyana_GWHPCBQA036196	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA036196
actinidia_hemsleyana_GWHPCBQA036197	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA036197
actinidia_hemsleyana_GWHPCBQA036251	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA036251