Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_hemsleyana_GWHPCBQA036993	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA036993
actinidia_hemsleyana_GWHPCBQA037691	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA037691
actinidia_hemsleyana_GWHPCBQA038018	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA038018
actinidia_hemsleyana_GWHPCBQA038534	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA038534
actinidia_hemsleyana_GWHPCBQA040100	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA040100
actinidia_hemsleyana_GWHPCBQA041107	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA041107
actinidia_hemsleyana_GWHPCBQA042734	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA042734
actinidia_hemsleyana_GWHPCBQA042850	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA042850
actinidia_hemsleyana_GWHPCBQA043586	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA043586
actinidia_hemsleyana_GWHPCBQA043971	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA043971
actinidia_hemsleyana_GWHPCBQA044064	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA044064
actinidia_hemsleyana_GWHPCBQA044243	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA044243
actinidia_hemsleyana_GWHPCBQA044299	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA044299
actinidia_hemsleyana_GWHPCBQA045106	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA045106
actinidia_hemsleyana_GWHPCBQA045259	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA045259
actinidia_hemsleyana_GWHPCBQA045263	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA045263
actinidia_hemsleyana_GWHPCBQA045264	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA045264
actinidia_hemsleyana_GWHPCBQA045358	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA045358
actinidia_hemsleyana_GWHPCBQA045374	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA045374
actinidia_hemsleyana_GWHPCBQA045697	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA045697
actinidia_hemsleyana_GWHPCBQA046529	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA046529
actinidia_zhejiangensis_GWHPCBQB000501	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB000501
actinidia_zhejiangensis_GWHPCBQB001225	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB001225
actinidia_zhejiangensis_GWHPCBQB002953	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB002953
actinidia_zhejiangensis_GWHPCBQB003863	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB003863
actinidia_zhejiangensis_GWHPCBQB004311	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB004311
actinidia_zhejiangensis_GWHPCBQB005107	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB005107
actinidia_zhejiangensis_GWHPCBQB005344	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB005344
actinidia_zhejiangensis_GWHPCBQB005434	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB005434
actinidia_zhejiangensis_GWHPCBQB005657	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB005657