Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB006470	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB006470
actinidia_zhejiangensis_GWHPCBQB007291	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB007291
actinidia_zhejiangensis_GWHPCBQB008159	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB008159
actinidia_zhejiangensis_GWHPCBQB008545	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB008545
actinidia_zhejiangensis_GWHPCBQB009174	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB009174
actinidia_zhejiangensis_GWHPCBQB009175	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB009175
actinidia_zhejiangensis_GWHPCBQB009176	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB009176
actinidia_zhejiangensis_GWHPCBQB009335	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB009335
actinidia_zhejiangensis_GWHPCBQB010179	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB010179
actinidia_zhejiangensis_GWHPCBQB010277	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB010277
actinidia_zhejiangensis_GWHPCBQB010477	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB010477
actinidia_zhejiangensis_GWHPCBQB010662	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB010662
actinidia_zhejiangensis_GWHPCBQB011114	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB011114
actinidia_zhejiangensis_GWHPCBQB011257	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB011257
actinidia_zhejiangensis_GWHPCBQB011951	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB011951
actinidia_zhejiangensis_GWHPCBQB013000	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB013000
actinidia_zhejiangensis_GWHPCBQB013417	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB013417
actinidia_zhejiangensis_GWHPCBQB014161	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB014161
actinidia_zhejiangensis_GWHPCBQB014163	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB014163
actinidia_zhejiangensis_GWHPCBQB014164	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB014164
actinidia_zhejiangensis_GWHPCBQB014165	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB014165
actinidia_zhejiangensis_GWHPCBQB014697	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB014697
actinidia_zhejiangensis_GWHPCBQB015253	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB015253
actinidia_zhejiangensis_GWHPCBQB015557	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB015557
actinidia_zhejiangensis_GWHPCBQB015569	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB015569
actinidia_zhejiangensis_GWHPCBQB015892	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB015892
actinidia_zhejiangensis_GWHPCBQB015893	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB015893
actinidia_zhejiangensis_GWHPCBQB015894	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB015894
actinidia_zhejiangensis_GWHPCBQB016021	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB016021
actinidia_zhejiangensis_GWHPCBQB016032	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB016032