Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB016284	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB016284
actinidia_zhejiangensis_GWHPCBQB016285	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB016285
actinidia_zhejiangensis_GWHPCBQB016313	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB016313
actinidia_zhejiangensis_GWHPCBQB017544	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB017544
actinidia_zhejiangensis_GWHPCBQB018418	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB018418
actinidia_zhejiangensis_GWHPCBQB019485	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB019485
actinidia_zhejiangensis_GWHPCBQB019553	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB019553
actinidia_zhejiangensis_GWHPCBQB019824	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB019824
actinidia_zhejiangensis_GWHPCBQB019825	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB019825
actinidia_zhejiangensis_GWHPCBQB019826	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB019826
actinidia_zhejiangensis_GWHPCBQB019830	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB019830
actinidia_zhejiangensis_GWHPCBQB020620	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB020620
actinidia_zhejiangensis_GWHPCBQB020661	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB020661
actinidia_zhejiangensis_GWHPCBQB021331	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021331
actinidia_zhejiangensis_GWHPCBQB021662	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021662
actinidia_zhejiangensis_GWHPCBQB021961	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021961
actinidia_zhejiangensis_GWHPCBQB021962	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021962
actinidia_zhejiangensis_GWHPCBQB021965	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021965
actinidia_zhejiangensis_GWHPCBQB021966	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021966
actinidia_zhejiangensis_GWHPCBQB021967	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021967
actinidia_zhejiangensis_GWHPCBQB021968	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB021968
actinidia_zhejiangensis_GWHPCBQB022416	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB022416
actinidia_zhejiangensis_GWHPCBQB022423	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB022423
actinidia_zhejiangensis_GWHPCBQB022834	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB022834
actinidia_zhejiangensis_GWHPCBQB022835	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB022835
actinidia_zhejiangensis_GWHPCBQB023554	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB023554
actinidia_zhejiangensis_GWHPCBQB024099	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB024099
actinidia_zhejiangensis_GWHPCBQB024282	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB024282
actinidia_zhejiangensis_GWHPCBQB024622	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB024622
actinidia_zhejiangensis_GWHPCBQB024769	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB024769