Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB025001	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB025001
actinidia_zhejiangensis_GWHPCBQB025217	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB025217
actinidia_zhejiangensis_GWHPCBQB026040	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB026040
actinidia_zhejiangensis_GWHPCBQB026687	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB026687
actinidia_zhejiangensis_GWHPCBQB027284	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB027284
actinidia_zhejiangensis_GWHPCBQB027446	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB027446
actinidia_zhejiangensis_GWHPCBQB027695	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB027695
actinidia_zhejiangensis_GWHPCBQB027928	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB027928
actinidia_zhejiangensis_GWHPCBQB027929	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB027929
actinidia_zhejiangensis_GWHPCBQB027930	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB027930
actinidia_zhejiangensis_GWHPCBQB027933	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB027933
actinidia_zhejiangensis_GWHPCBQB028726	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB028726
actinidia_zhejiangensis_GWHPCBQB028728	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB028728
actinidia_zhejiangensis_GWHPCBQB029156	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB029156
actinidia_zhejiangensis_GWHPCBQB029886	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB029886
actinidia_zhejiangensis_GWHPCBQB030072	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB030072
actinidia_zhejiangensis_GWHPCBQB030800	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB030800
actinidia_zhejiangensis_GWHPCBQB030801	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB030801
actinidia_zhejiangensis_GWHPCBQB030802	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB030802
actinidia_zhejiangensis_GWHPCBQB031661	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB031661
actinidia_zhejiangensis_GWHPCBQB032716	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB032716
actinidia_zhejiangensis_GWHPCBQB032718	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB032718
actinidia_zhejiangensis_GWHPCBQB032853	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB032853
actinidia_zhejiangensis_GWHPCBQB033294	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB033294
actinidia_zhejiangensis_GWHPCBQB033486	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB033486
actinidia_zhejiangensis_GWHPCBQB033834	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB033834
actinidia_zhejiangensis_GWHPCBQB034040	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB034040
actinidia_zhejiangensis_GWHPCBQB034454	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB034454
actinidia_zhejiangensis_GWHPCBQB034455	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB034455
actinidia_zhejiangensis_GWHPCBQB035115	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB035115