Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT14389 SQE4569 CAS35857

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT327781 SMO1/SMO24067 CPI11261 CYP51G1190 FK1234 HYD11364 DWF71524 DWF5888 DWF11689

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET21316 DWF4/CYP90B1290 CPD/CYP90A1103 ROT3/CYP90C1193 CYP90D1142 BR6OX1/CYP85A140 BR6OX2/CYP85A268

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Algae (569) Bryophytes (5698) Lycophytes/Ferns (189) Gymnosperms (791) Basal angiosperms (1411) Monocots (17019) Eudicots (61245)

Species Distribution

Lineage Summary

Module Gene List

Gene	Species	Protein ID
Aurv8876670205190	acrobolbus_urvilleanus	Aurv8876670205190
Aurv8908440215250	acrobolbus_urvilleanus	Aurv8908440215250
Aurv8913640216530	acrobolbus_urvilleanus	Aurv8913640216530
Aurv8932920222420	acrobolbus_urvilleanus	Aurv8932920222420
Aurv8953820229300	acrobolbus_urvilleanus	Aurv8953820229300
Aurv9013610251940	acrobolbus_urvilleanus	Aurv9013610251940
Aurv9034100259240	acrobolbus_urvilleanus	Aurv9034100259240
Aurv9051000266730	acrobolbus_urvilleanus	Aurv9051000266730
Aurv9072720275430	acrobolbus_urvilleanus	Aurv9072720275430
Aurv9073220275670	acrobolbus_urvilleanus	Aurv9073220275670
Aurv9083760280140	acrobolbus_urvilleanus	Aurv9083760280140
Aurv9084400280440	acrobolbus_urvilleanus	Aurv9084400280440
Aurv9094970285160	acrobolbus_urvilleanus	Aurv9094970285160
Aurv9103190289100	acrobolbus_urvilleanus	Aurv9103190289100
Aurv9168000317700	acrobolbus_urvilleanus	Aurv9168000317700
Aurv9174630320510	acrobolbus_urvilleanus	Aurv9174630320510
Aurv9176720321280	acrobolbus_urvilleanus	Aurv9176720321280
Aurv9209480333720	acrobolbus_urvilleanus	Aurv9209480333720
Aurv9213560335400	acrobolbus_urvilleanus	Aurv9213560335400
Aurv9235020342630	acrobolbus_urvilleanus	Aurv9235020342630
Aurv9265580353530	acrobolbus_urvilleanus	Aurv9265580353530
Aurv9285240360430	acrobolbus_urvilleanus	Aurv9285240360430
Achi01G0001170.1	actinidia_chinensis	Achi01G0001170.1
Achi01G0005380.1	actinidia_chinensis	Achi01G0005380.1
Achi01G0007310.1	actinidia_chinensis	Achi01G0007310.1
Achi02G0008580.1	actinidia_chinensis	Achi02G0008580.1
Achi03G0004250.1	actinidia_chinensis	Achi03G0004250.1
Achi03G0011190.1	actinidia_chinensis	Achi03G0011190.1
Achi03G0011780.1	actinidia_chinensis	Achi03G0011780.1
Achi03G0014110.1	actinidia_chinensis	Achi03G0014110.1