Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB047384	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB047384
actinidia_zhejiangensis_GWHPCBQB047387	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB047387
actinidia_zhejiangensis_GWHPCBQB047388	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB047388
actinidia_zhejiangensis_GWHPCBQB047389	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB047389
actinidia_zhejiangensis_GWHPCBQB047391	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB047391
actinidia_zhejiangensis_GWHPCBQB047489	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB047489
actinidia_zhejiangensis_GWHPCBQB047854	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB047854
actinidia_zhejiangensis_GWHPCBQB048702	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB048702
actinidia_zhejiangensis_GWHPCBQB049217	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB049217
actinidia_zhejiangensis_GWHPCBQB049961	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB049961
actinidia_zhejiangensis_GWHPCBQB051090	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB051090
actinidia_zhejiangensis_GWHPCBQB052583	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB052583
actinidia_zhejiangensis_GWHPCBQB053596	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB053596
actinidia_zhejiangensis_GWHPCBQB053866	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB053866
actinidia_zhejiangensis_GWHPCBQB053867	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB053867
actinidia_zhejiangensis_GWHPCBQB054089	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB054089
actinidia_zhejiangensis_GWHPCBQB054402	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB054402
actinidia_zhejiangensis_GWHPCBQB055194	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB055194
actinidia_zhejiangensis_GWHPCBQB056052	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB056052
actinidia_zhejiangensis_GWHPCBQB056909	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB056909
actinidia_zhejiangensis_GWHPCBQB057312	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB057312
actinidia_zhejiangensis_GWHPCBQB057856	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB057856
actinidia_zhejiangensis_GWHPCBQB059021	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB059021
actinidia_zhejiangensis_GWHPCBQB059228	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB059228
actinidia_zhejiangensis_GWHPCBQB059404	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB059404
actinidia_zhejiangensis_GWHPCBQB059834	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB059834
actinidia_zhejiangensis_GWHPCBQB059969	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB059969
actinidia_zhejiangensis_GWHPCBQB060706	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB060706
actinidia_zhejiangensis_GWHPCBQB061812	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB061812
actinidia_zhejiangensis_GWHPCBQB062202	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB062202