Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB062649	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB062649
actinidia_zhejiangensis_GWHPCBQB062989	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB062989
actinidia_zhejiangensis_GWHPCBQB063523	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB063523
actinidia_zhejiangensis_GWHPCBQB064705	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB064705
actinidia_zhejiangensis_GWHPCBQB064706	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB064706
actinidia_zhejiangensis_GWHPCBQB064707	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB064707
actinidia_zhejiangensis_GWHPCBQB064708	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB064708
actinidia_zhejiangensis_GWHPCBQB064860	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB064860
actinidia_zhejiangensis_GWHPCBQB064872	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB064872
actinidia_zhejiangensis_GWHPCBQB065074	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB065074
actinidia_zhejiangensis_GWHPCBQB065102	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB065102
actinidia_zhejiangensis_GWHPCBQB065103	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB065103
actinidia_zhejiangensis_GWHPCBQB066303	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB066303
actinidia_zhejiangensis_GWHPCBQB066304	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB066304
actinidia_zhejiangensis_GWHPCBQB067875	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB067875
actinidia_zhejiangensis_GWHPCBQB068206	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068206
actinidia_zhejiangensis_GWHPCBQB068221	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068221
actinidia_zhejiangensis_GWHPCBQB068222	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068222
actinidia_zhejiangensis_GWHPCBQB068282	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068282
actinidia_zhejiangensis_GWHPCBQB068599	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068599
actinidia_zhejiangensis_GWHPCBQB068603	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068603
actinidia_zhejiangensis_GWHPCBQB068604	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068604
actinidia_zhejiangensis_GWHPCBQB068605	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068605
actinidia_zhejiangensis_GWHPCBQB068607	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068607
actinidia_zhejiangensis_GWHPCBQB068609	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068609
actinidia_zhejiangensis_GWHPCBQB068610	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068610
actinidia_zhejiangensis_GWHPCBQB068611	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB068611
actinidia_zhejiangensis_GWHPCBQB069509	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB069509
actinidia_zhejiangensis_GWHPCBQB070168	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB070168
actinidia_zhejiangensis_GWHPCBQB070169	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB070169