Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB070170	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB070170
actinidia_zhejiangensis_GWHPCBQB070537	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB070537
actinidia_zhejiangensis_GWHPCBQB070816	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB070816
actinidia_zhejiangensis_GWHPCBQB070837	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB070837
actinidia_zhejiangensis_GWHPCBQB071288	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB071288
actinidia_zhejiangensis_GWHPCBQB071289	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB071289
actinidia_zhejiangensis_GWHPCBQB071715	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB071715
actinidia_zhejiangensis_GWHPCBQB071716	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB071716
actinidia_zhejiangensis_GWHPCBQB072414	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB072414
actinidia_zhejiangensis_GWHPCBQB073579	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB073579
actinidia_zhejiangensis_GWHPCBQB073742	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB073742
actinidia_zhejiangensis_GWHPCBQB073746	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB073746
actinidia_zhejiangensis_GWHPCBQB073747	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB073747
actinidia_zhejiangensis_GWHPCBQB073749	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB073749
actinidia_zhejiangensis_GWHPCBQB073962	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB073962
actinidia_zhejiangensis_GWHPCBQB074178	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB074178
actinidia_zhejiangensis_GWHPCBQB075071	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB075071
actinidia_zhejiangensis_GWHPCBQB075072	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB075072
actinidia_zhejiangensis_GWHPCBQB075716	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB075716
actinidia_zhejiangensis_GWHPCBQB075794	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB075794
actinidia_zhejiangensis_GWHPCBQB075795	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB075795
actinidia_zhejiangensis_GWHPCBQB076328	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076328
actinidia_zhejiangensis_GWHPCBQB076329	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076329
actinidia_zhejiangensis_GWHPCBQB076969	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076969
actinidia_zhejiangensis_GWHPCBQB076970	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076970
actinidia_zhejiangensis_GWHPCBQB076973	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076973
actinidia_zhejiangensis_GWHPCBQB076976	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076976
actinidia_zhejiangensis_GWHPCBQB076977	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076977
actinidia_zhejiangensis_GWHPCBQB077754	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB077754
actinidia_zhejiangensis_GWHPCBQB077756	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB077756