Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT14389 SQE4569 CAS35857

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT327781 SMO1/SMO24067 CPI11261 CYP51G1190 FK1234 HYD11364 DWF71524 DWF5888 DWF11689

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET21316 DWF4/CYP90B1290 CPD/CYP90A1103 ROT3/CYP90C1193 CYP90D1142 BR6OX1/CYP85A140 BR6OX2/CYP85A268

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Algae (569) Bryophytes (5698) Lycophytes/Ferns (189) Gymnosperms (791) Basal angiosperms (1411) Monocots (17019) Eudicots (61245)

Species Distribution

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB033834	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB033834
actinidia_zhejiangensis_GWHPCBQB034040	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB034040
actinidia_zhejiangensis_GWHPCBQB034454	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB034454
actinidia_zhejiangensis_GWHPCBQB034455	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB034455
actinidia_zhejiangensis_GWHPCBQB035115	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB035115
actinidia_zhejiangensis_GWHPCBQB035704	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB035704
actinidia_zhejiangensis_GWHPCBQB036199	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB036199
actinidia_zhejiangensis_GWHPCBQB036456	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB036456
actinidia_zhejiangensis_GWHPCBQB036643	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB036643
actinidia_zhejiangensis_GWHPCBQB036644	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB036644
actinidia_zhejiangensis_GWHPCBQB036645	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB036645
actinidia_zhejiangensis_GWHPCBQB037154	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB037154
actinidia_zhejiangensis_GWHPCBQB037155	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB037155
actinidia_zhejiangensis_GWHPCBQB037174	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB037174
actinidia_zhejiangensis_GWHPCBQB037175	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB037175
actinidia_zhejiangensis_GWHPCBQB037850	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB037850
actinidia_zhejiangensis_GWHPCBQB038663	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB038663
actinidia_zhejiangensis_GWHPCBQB039335	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB039335
actinidia_zhejiangensis_GWHPCBQB039406	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB039406
actinidia_zhejiangensis_GWHPCBQB039750	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB039750
actinidia_zhejiangensis_GWHPCBQB040178	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB040178
actinidia_zhejiangensis_GWHPCBQB040180	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB040180
actinidia_zhejiangensis_GWHPCBQB040319	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB040319
actinidia_zhejiangensis_GWHPCBQB041105	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB041105
actinidia_zhejiangensis_GWHPCBQB041952	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB041952
actinidia_zhejiangensis_GWHPCBQB043128	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB043128
actinidia_zhejiangensis_GWHPCBQB043129	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB043129
actinidia_zhejiangensis_GWHPCBQB044675	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB044675
actinidia_zhejiangensis_GWHPCBQB044785	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB044785
actinidia_zhejiangensis_GWHPCBQB044786	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB044786