Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT14389 SQE4569 CAS35857

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT327781 SMO1/SMO24067 CPI11261 CYP51G1190 FK1234 HYD11364 DWF71524 DWF5888 DWF11689

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET21316 DWF4/CYP90B1290 CPD/CYP90A1103 ROT3/CYP90C1193 CYP90D1142 BR6OX1/CYP85A140 BR6OX2/CYP85A268

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Algae (569) Bryophytes (5698) Lycophytes/Ferns (189) Gymnosperms (791) Basal angiosperms (1411) Monocots (17019) Eudicots (61245)

Species Distribution

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB076973	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076973
actinidia_zhejiangensis_GWHPCBQB076976	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076976
actinidia_zhejiangensis_GWHPCBQB076977	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB076977
actinidia_zhejiangensis_GWHPCBQB077754	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB077754
actinidia_zhejiangensis_GWHPCBQB077756	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB077756
actinidia_zhejiangensis_GWHPCBQB077757	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB077757
actinidia_zhejiangensis_GWHPCBQB077758	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB077758
actinidia_zhejiangensis_GWHPCBQB078165	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB078165
actinidia_zhejiangensis_GWHPCBQB078166	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB078166
actinidia_zhejiangensis_GWHPCBQB078926	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB078926
actinidia_zhejiangensis_GWHPCBQB079527	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB079527
actinidia_zhejiangensis_GWHPCBQB079892	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB079892
actinidia_zhejiangensis_GWHPCBQB080790	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB080790
actinidia_zhejiangensis_GWHPCBQB081872	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB081872
actinidia_zhejiangensis_GWHPCBQB081874	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB081874
actinidia_zhejiangensis_GWHPCBQB081875	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB081875
actinidia_zhejiangensis_GWHPCBQB082020	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB082020
actinidia_zhejiangensis_GWHPCBQB082476	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB082476
actinidia_zhejiangensis_GWHPCBQB082642	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB082642
actinidia_zhejiangensis_GWHPCBQB083178	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB083178
actinidia_zhejiangensis_GWHPCBQB083601	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB083601
actinidia_zhejiangensis_GWHPCBQB083602	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB083602
actinidia_zhejiangensis_GWHPCBQB084323	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB084323
actinidia_zhejiangensis_GWHPCBQB085363	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB085363
actinidia_zhejiangensis_GWHPCBQB085635	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB085635
actinidia_zhejiangensis_GWHPCBQB085819	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB085819
actinidia_zhejiangensis_GWHPCBQB085820	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB085820
actinidia_zhejiangensis_GWHPCBQB086340	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB086340
actinidia_zhejiangensis_GWHPCBQB086341	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB086341
actinidia_zhejiangensis_GWHPCBQB086363	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB086363