Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
alnus_rubra_ALNRU00041694-RA	alnus_rubra	alnus_rubra_ALNRU00041694-RA
alnus_rubra_ALNRU00042204-RA	alnus_rubra	alnus_rubra_ALNRU00042204-RA
alnus_rubra_ALNRU00045783-RA	alnus_rubra	alnus_rubra_ALNRU00045783-RA
alnus_rubra_ALNRU00046739-RA	alnus_rubra	alnus_rubra_ALNRU00046739-RA
alnus_rubra_ALNRU00054242-RA	alnus_rubra	alnus_rubra_ALNRU00054242-RA
alnus_rubra_ALNRU00054244-RA	alnus_rubra	alnus_rubra_ALNRU00054244-RA
alnus_rubra_ALNRU00054246-RA	alnus_rubra	alnus_rubra_ALNRU00054246-RA
alnus_rubra_ALNRU00054255-RA	alnus_rubra	alnus_rubra_ALNRU00054255-RA
alnus_rubra_ALNRU00054264-RA	alnus_rubra	alnus_rubra_ALNRU00054264-RA
alnus_rubra_ALNRU00054265-RA	alnus_rubra	alnus_rubra_ALNRU00054265-RA
alnus_rubra_ALNRU00054443-RA	alnus_rubra	alnus_rubra_ALNRU00054443-RA
alnus_rubra_ALNRU00054907-RA	alnus_rubra	alnus_rubra_ALNRU00054907-RA
alnus_rubra_ALNRU00055180-RA	alnus_rubra	alnus_rubra_ALNRU00055180-RA
alnus_rubra_ALNRU00055762-RA	alnus_rubra	alnus_rubra_ALNRU00055762-RA
alnus_rubra_ALNRU00059967-RA	alnus_rubra	alnus_rubra_ALNRU00059967-RA
alnus_rubra_ALNRU00063634-RA	alnus_rubra	alnus_rubra_ALNRU00063634-RA
alnus_rubra_ALNRU00064325-RA	alnus_rubra	alnus_rubra_ALNRU00064325-RA
alnus_rubra_ALNRU00065523-RA	alnus_rubra	alnus_rubra_ALNRU00065523-RA
alnus_rubra_ALNRU00065532-RA	alnus_rubra	alnus_rubra_ALNRU00065532-RA
alnus_rubra_ALNRU00065547-RA	alnus_rubra	alnus_rubra_ALNRU00065547-RA
alnus_rubra_ALNRU00065552-RA	alnus_rubra	alnus_rubra_ALNRU00065552-RA
alnus_rubra_ALNRU00065557-RA	alnus_rubra	alnus_rubra_ALNRU00065557-RA
alnus_rubra_ALNRU00065573-RA	alnus_rubra	alnus_rubra_ALNRU00065573-RA
alnus_rubra_ALNRU00065576-RA	alnus_rubra	alnus_rubra_ALNRU00065576-RA
alnus_rubra_ALNRU00065577-RA	alnus_rubra	alnus_rubra_ALNRU00065577-RA
alnus_rubra_ALNRU00065580-RA	alnus_rubra	alnus_rubra_ALNRU00065580-RA
alnus_rubra_ALNRU00065583-RA	alnus_rubra	alnus_rubra_ALNRU00065583-RA
alnus_rubra_ALNRU00065587-RA	alnus_rubra	alnus_rubra_ALNRU00065587-RA
alnus_rubra_ALNRU00065588-RA	alnus_rubra	alnus_rubra_ALNRU00065588-RA
alnus_rubra_ALNRU00065690-RA	alnus_rubra	alnus_rubra_ALNRU00065690-RA