Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
alnus_rubra_ALNRU00071474-RA	alnus_rubra	alnus_rubra_ALNRU00071474-RA
alnus_rubra_ALNRU00071475-RA	alnus_rubra	alnus_rubra_ALNRU00071475-RA
alnus_rubra_ALNRU00073112-RA	alnus_rubra	alnus_rubra_ALNRU00073112-RA
alnus_rubra_ALNRU00075167-RA	alnus_rubra	alnus_rubra_ALNRU00075167-RA
alnus_rubra_ALNRU00079943-RA	alnus_rubra	alnus_rubra_ALNRU00079943-RA
alnus_rubra_ALNRU00080958-RA	alnus_rubra	alnus_rubra_ALNRU00080958-RA
alnus_rubra_ALNRU00084357-RA	alnus_rubra	alnus_rubra_ALNRU00084357-RA
alnus_rubra_ALNRU00086385-RA	alnus_rubra	alnus_rubra_ALNRU00086385-RA
alnus_rubra_ALNRU00086532-RA	alnus_rubra	alnus_rubra_ALNRU00086532-RA
alnus_rubra_ALNRU00088130-RA	alnus_rubra	alnus_rubra_ALNRU00088130-RA
alnus_rubra_ALNRU00088131-RA	alnus_rubra	alnus_rubra_ALNRU00088131-RA
alnus_rubra_ALNRU00088135-RA	alnus_rubra	alnus_rubra_ALNRU00088135-RA
alnus_rubra_ALNRU00089001-RA	alnus_rubra	alnus_rubra_ALNRU00089001-RA
alnus_rubra_ALNRU00089541-RA	alnus_rubra	alnus_rubra_ALNRU00089541-RA
alnus_rubra_ALNRU00091836-RA	alnus_rubra	alnus_rubra_ALNRU00091836-RA
alnus_rubra_ALNRU00093417-RA	alnus_rubra	alnus_rubra_ALNRU00093417-RA
alnus_rubra_ALNRU00093419-RA	alnus_rubra	alnus_rubra_ALNRU00093419-RA
alnus_rubra_ALNRU00093424-RA	alnus_rubra	alnus_rubra_ALNRU00093424-RA
alnus_rubra_ALNRU00093435-RA	alnus_rubra	alnus_rubra_ALNRU00093435-RA
alnus_rubra_ALNRU00093447-RA	alnus_rubra	alnus_rubra_ALNRU00093447-RA
alnus_rubra_ALNRU00093451-RA	alnus_rubra	alnus_rubra_ALNRU00093451-RA
alnus_rubra_ALNRU00096030-RA	alnus_rubra	alnus_rubra_ALNRU00096030-RA
alnus_rubra_ALNRU00096034-RA	alnus_rubra	alnus_rubra_ALNRU00096034-RA
alnus_rubra_ALNRU00096044-RA	alnus_rubra	alnus_rubra_ALNRU00096044-RA
alnus_rubra_ALNRU00096053-RA	alnus_rubra	alnus_rubra_ALNRU00096053-RA
alnus_rubra_ALNRU00096054-RA	alnus_rubra	alnus_rubra_ALNRU00096054-RA
alnus_rubra_ALNRU00096065-RA	alnus_rubra	alnus_rubra_ALNRU00096065-RA
alnus_rubra_ALNRU00096067-RA	alnus_rubra	alnus_rubra_ALNRU00096067-RA
alnus_rubra_ALNRU00096069-RA	alnus_rubra	alnus_rubra_ALNRU00096069-RA
alnus_rubra_ALNRU00096094-RA	alnus_rubra	alnus_rubra_ALNRU00096094-RA