Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
alnus_rubra_ALNRU00096095-RA	alnus_rubra	alnus_rubra_ALNRU00096095-RA
alnus_rubra_ALNRU00096980-RA	alnus_rubra	alnus_rubra_ALNRU00096980-RA
alnus_rubra_ALNRU00098295-RA	alnus_rubra	alnus_rubra_ALNRU00098295-RA
alnus_rubra_ALNRU00100228-RA	alnus_rubra	alnus_rubra_ALNRU00100228-RA
alnus_rubra_ALNRU00100241-RA	alnus_rubra	alnus_rubra_ALNRU00100241-RA
alnus_rubra_ALNRU00101568-RA	alnus_rubra	alnus_rubra_ALNRU00101568-RA
alnus_rubra_ALNRU00101581-RA	alnus_rubra	alnus_rubra_ALNRU00101581-RA
alnus_rubra_ALNRU00104413-RA	alnus_rubra	alnus_rubra_ALNRU00104413-RA
alnus_rubra_ALNRU00104424-RA	alnus_rubra	alnus_rubra_ALNRU00104424-RA
alnus_rubra_ALNRU00104425-RA	alnus_rubra	alnus_rubra_ALNRU00104425-RA
alnus_rubra_ALNRU00105799-RA	alnus_rubra	alnus_rubra_ALNRU00105799-RA
alnus_rubra_ALNRU00105808-RA	alnus_rubra	alnus_rubra_ALNRU00105808-RA
alnus_rubra_ALNRU00105812-RA	alnus_rubra	alnus_rubra_ALNRU00105812-RA
alnus_rubra_ALNRU00106496-RA	alnus_rubra	alnus_rubra_ALNRU00106496-RA
alnus_rubra_ALNRU00109199-RA	alnus_rubra	alnus_rubra_ALNRU00109199-RA
alnus_rubra_ALNRU00111970-RA	alnus_rubra	alnus_rubra_ALNRU00111970-RA
alnus_rubra_ALNRU00112017-RA	alnus_rubra	alnus_rubra_ALNRU00112017-RA
alnus_rubra_ALNRU00112026-RA	alnus_rubra	alnus_rubra_ALNRU00112026-RA
alnus_rubra_ALNRU00112034-RA	alnus_rubra	alnus_rubra_ALNRU00112034-RA
alnus_rubra_ALNRU00112060-RA	alnus_rubra	alnus_rubra_ALNRU00112060-RA
alnus_rubra_ALNRU00114832-RA	alnus_rubra	alnus_rubra_ALNRU00114832-RA
alnus_rubra_ALNRU00114901-RA	alnus_rubra	alnus_rubra_ALNRU00114901-RA
alnus_rubra_ALNRU00114908-RA	alnus_rubra	alnus_rubra_ALNRU00114908-RA
alnus_rubra_ALNRU00115729-RA	alnus_rubra	alnus_rubra_ALNRU00115729-RA
alnus_rubra_ALNRU00124466-RA	alnus_rubra	alnus_rubra_ALNRU00124466-RA
alnus_rubra_ALNRU00124473-RA	alnus_rubra	alnus_rubra_ALNRU00124473-RA
alnus_rubra_ALNRU00124479-RA	alnus_rubra	alnus_rubra_ALNRU00124479-RA
alnus_rubra_ALNRU00124480-RA	alnus_rubra	alnus_rubra_ALNRU00124480-RA
alnus_rubra_ALNRU00124484-RA	alnus_rubra	alnus_rubra_ALNRU00124484-RA
alnus_rubra_ALNRU00125563-RA	alnus_rubra	alnus_rubra_ALNRU00125563-RA