Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
AcruScioBoG_102839_HRSCAF_1030930049450.1	amaranthus_cruentus	AcruScioBoG_102839_HRSCAF_1030930049450.1
AcruScioBoG_102839_HRSCAF_1030930049450.2	amaranthus_cruentus	AcruScioBoG_102839_HRSCAF_1030930049450.2
AcruScioBoG_102839_HRSCAF_1030930049450.3	amaranthus_cruentus	AcruScioBoG_102839_HRSCAF_1030930049450.3
AcruScioBoG_102839_HRSCAF_1030930049450.4	amaranthus_cruentus	AcruScioBoG_102839_HRSCAF_1030930049450.4
AcruScioBoG_102839_HRSCAF_1030930050770.1	amaranthus_cruentus	AcruScioBoG_102839_HRSCAF_1030930050770.1
AcruScioBoG_102839_HRSCAF_1030930052290.1	amaranthus_cruentus	AcruScioBoG_102839_HRSCAF_1030930052290.1
AcruScioBoG_102840_HRSCAF_1030990059550.1	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990059550.1
AcruScioBoG_102840_HRSCAF_1030990061520.1	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990061520.1
AcruScioBoG_102840_HRSCAF_1030990061530.1	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990061530.1
AcruScioBoG_102840_HRSCAF_1030990061530.2	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990061530.2
AcruScioBoG_102840_HRSCAF_1030990061540.1	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990061540.1
AcruScioBoG_102840_HRSCAF_1030990061540.2	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990061540.2
AcruScioBoG_102840_HRSCAF_1030990061540.3	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990061540.3
AcruScioBoG_102840_HRSCAF_1030990062280.1	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990062280.1
AcruScioBoG_102840_HRSCAF_1030990062280.2	amaranthus_cruentus	AcruScioBoG_102840_HRSCAF_1030990062280.2
AcruScioBoG_102841_HRSCAF_1031140066380.1	amaranthus_cruentus	AcruScioBoG_102841_HRSCAF_1031140066380.1
AcruScioBoG_102841_HRSCAF_1031140068080.1	amaranthus_cruentus	AcruScioBoG_102841_HRSCAF_1031140068080.1
AcruScioBoG_11560_HRSCAF_116090075780.1	amaranthus_cruentus	AcruScioBoG_11560_HRSCAF_116090075780.1
AcruScioBoG_11560_HRSCAF_116090075780.3	amaranthus_cruentus	AcruScioBoG_11560_HRSCAF_116090075780.3
AcruScioBoG_12795_HRSCAF_128480079110.1	amaranthus_cruentus	AcruScioBoG_12795_HRSCAF_128480079110.1
AcruScioBoG_12795_HRSCAF_128480082250.1	amaranthus_cruentus	AcruScioBoG_12795_HRSCAF_128480082250.1
AcruScioBoG_12795_HRSCAF_128480082380.1	amaranthus_cruentus	AcruScioBoG_12795_HRSCAF_128480082380.1
AcruScioBoG_13798_HRSCAF_138620086370.1	amaranthus_cruentus	AcruScioBoG_13798_HRSCAF_138620086370.1
AcruScioBoG_13798_HRSCAF_138620086370.2	amaranthus_cruentus	AcruScioBoG_13798_HRSCAF_138620086370.2
AcruScioBoG_13798_HRSCAF_138620086370.3	amaranthus_cruentus	AcruScioBoG_13798_HRSCAF_138620086370.3
AcruScioBoG_13798_HRSCAF_138620088190.1	amaranthus_cruentus	AcruScioBoG_13798_HRSCAF_138620088190.1
AcruScioBoG_14204_HRSCAF_142700091710.1	amaranthus_cruentus	AcruScioBoG_14204_HRSCAF_142700091710.1
AcruScioBoG_14204_HRSCAF_142700091710.2	amaranthus_cruentus	AcruScioBoG_14204_HRSCAF_142700091710.2
AcruScioBoG_14204_HRSCAF_142700091710.3	amaranthus_cruentus	AcruScioBoG_14204_HRSCAF_142700091710.3
AcruScioBoG_17730_HRSCAF_178110099210.1	amaranthus_cruentus	AcruScioBoG_17730_HRSCAF_178110099210.1