Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
AcruScioBoG_17730_HRSCAF_178110103570.1	amaranthus_cruentus	AcruScioBoG_17730_HRSCAF_178110103570.1
AcruScioBoG_17730_HRSCAF_178110104330.1	amaranthus_cruentus	AcruScioBoG_17730_HRSCAF_178110104330.1
AcruScioBoG_17730_HRSCAF_178110105190.1	amaranthus_cruentus	AcruScioBoG_17730_HRSCAF_178110105190.1
AcruScioBoG_18778_HRSCAF_188630110680.1	amaranthus_cruentus	AcruScioBoG_18778_HRSCAF_188630110680.1
AcruScioBoG_18778_HRSCAF_188630110680.2	amaranthus_cruentus	AcruScioBoG_18778_HRSCAF_188630110680.2
AcruScioBoG_18778_HRSCAF_188630110680.3	amaranthus_cruentus	AcruScioBoG_18778_HRSCAF_188630110680.3
AcruScioBoG_19538_HRSCAF_196260123530.1	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260123530.1
AcruScioBoG_19538_HRSCAF_196260126570.1	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260126570.1
AcruScioBoG_19538_HRSCAF_196260128550.1	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260128550.1
AcruScioBoG_19538_HRSCAF_196260129010.1	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260129010.1
AcruScioBoG_19538_HRSCAF_196260129010.2	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260129010.2
AcruScioBoG_19538_HRSCAF_196260129010.3	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260129010.3
AcruScioBoG_19538_HRSCAF_196260131110.2	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260131110.2
AcruScioBoG_19538_HRSCAF_196260132560.1	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260132560.1
AcruScioBoG_19538_HRSCAF_196260132560.2	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260132560.2
AcruScioBoG_19538_HRSCAF_196260132560.3	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260132560.3
AcruScioBoG_19538_HRSCAF_196260133880.1	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260133880.1
AcruScioBoG_19538_HRSCAF_196260134570.1	amaranthus_cruentus	AcruScioBoG_19538_HRSCAF_196260134570.1
AcruScioBoG_19743_HRSCAF_198340138890.1	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340138890.1
AcruScioBoG_19743_HRSCAF_198340138890.2	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340138890.2
AcruScioBoG_19743_HRSCAF_198340139140.1	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340139140.1
AcruScioBoG_19743_HRSCAF_198340139140.2	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340139140.2
AcruScioBoG_19743_HRSCAF_198340139350.1	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340139350.1
AcruScioBoG_19743_HRSCAF_198340139550.1	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340139550.1
AcruScioBoG_19743_HRSCAF_198340142350.1	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340142350.1
AcruScioBoG_19743_HRSCAF_198340142360.1	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340142360.1
AcruScioBoG_19743_HRSCAF_198340142930.1	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340142930.1
AcruScioBoG_19743_HRSCAF_198340142930.2	amaranthus_cruentus	AcruScioBoG_19743_HRSCAF_198340142930.2
AcruScioBoG_19834_HRSCAF_199250144930.1	amaranthus_cruentus	AcruScioBoG_19834_HRSCAF_199250144930.1
AcruScioBoG_19834_HRSCAF_199250145040.1	amaranthus_cruentus	AcruScioBoG_19834_HRSCAF_199250145040.1