Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
AcruScioBoG_26180_HRSCAF_263060166860.9	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166860.9
AcruScioBoG_26180_HRSCAF_263060166870.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166870.1
AcruScioBoG_26180_HRSCAF_263060166870.3	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166870.3
AcruScioBoG_26180_HRSCAF_263060166870.5	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166870.5
AcruScioBoG_26180_HRSCAF_263060166880.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166880.1
AcruScioBoG_26180_HRSCAF_263060166890.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166890.1
AcruScioBoG_26180_HRSCAF_263060166900.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166900.1
AcruScioBoG_26180_HRSCAF_263060166900.2	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166900.2
AcruScioBoG_26180_HRSCAF_263060166900.3	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166900.3
AcruScioBoG_26180_HRSCAF_263060166900.4	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166900.4
AcruScioBoG_26180_HRSCAF_263060166910.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166910.1
AcruScioBoG_26180_HRSCAF_263060166910.2	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166910.2
AcruScioBoG_26180_HRSCAF_263060166910.3	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166910.3
AcruScioBoG_26180_HRSCAF_263060166910.4	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166910.4
AcruScioBoG_26180_HRSCAF_263060166910.5	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166910.5
AcruScioBoG_26180_HRSCAF_263060166910.6	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166910.6
AcruScioBoG_26180_HRSCAF_263060166910.7	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166910.7
AcruScioBoG_26180_HRSCAF_263060166930.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166930.1
AcruScioBoG_26180_HRSCAF_263060166940.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060166940.1
AcruScioBoG_26180_HRSCAF_263060169650.1	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060169650.1
AcruScioBoG_26180_HRSCAF_263060169650.2	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060169650.2
AcruScioBoG_26180_HRSCAF_263060169650.3	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060169650.3
AcruScioBoG_26180_HRSCAF_263060169650.4	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060169650.4
AcruScioBoG_26180_HRSCAF_263060169650.5	amaranthus_cruentus	AcruScioBoG_26180_HRSCAF_263060169650.5
AcruScioBoG_26769_HRSCAF_268990175430.1	amaranthus_cruentus	AcruScioBoG_26769_HRSCAF_268990175430.1
AcruScioBoG_26769_HRSCAF_268990177750.1	amaranthus_cruentus	AcruScioBoG_26769_HRSCAF_268990177750.1
AcruScioBoG_3008_HRSCAF_30150180380.1	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150180380.1
AcruScioBoG_3008_HRSCAF_30150180380.2	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150180380.2
AcruScioBoG_3008_HRSCAF_30150180380.3	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150180380.3
AcruScioBoG_3008_HRSCAF_30150180380.4	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150180380.4