Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
AcruScioBoG_3008_HRSCAF_30150183150.1	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183150.1
AcruScioBoG_3008_HRSCAF_30150183150.2	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183150.2
AcruScioBoG_3008_HRSCAF_30150183320.1	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183320.1
AcruScioBoG_3008_HRSCAF_30150183320.2	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183320.2
AcruScioBoG_3008_HRSCAF_30150183330.1	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183330.1
AcruScioBoG_3008_HRSCAF_30150183340.1	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183340.1
AcruScioBoG_3008_HRSCAF_30150183340.2	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183340.2
AcruScioBoG_3008_HRSCAF_30150183340.3	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183340.3
AcruScioBoG_3008_HRSCAF_30150183340.4	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183340.4
AcruScioBoG_3008_HRSCAF_30150183340.5	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183340.5
AcruScioBoG_3008_HRSCAF_30150183350.1	amaranthus_cruentus	AcruScioBoG_3008_HRSCAF_30150183350.1
AcruScioBoG_3703_HRSCAF_37190188750.1	amaranthus_cruentus	AcruScioBoG_3703_HRSCAF_37190188750.1
AcruScioBoG_3895_HRSCAF_39120194610.1	amaranthus_cruentus	AcruScioBoG_3895_HRSCAF_39120194610.1
AcruScioBoG_3895_HRSCAF_39120194610.2	amaranthus_cruentus	AcruScioBoG_3895_HRSCAF_39120194610.2
AcruScioBoG_3895_HRSCAF_39120195170.1	amaranthus_cruentus	AcruScioBoG_3895_HRSCAF_39120195170.1
AcruScioBoG_3895_HRSCAF_39120195170.3	amaranthus_cruentus	AcruScioBoG_3895_HRSCAF_39120195170.3
AcruScioBoG_3895_HRSCAF_39120195170.4	amaranthus_cruentus	AcruScioBoG_3895_HRSCAF_39120195170.4
AcruScioBoG_3895_HRSCAF_39120195170.6	amaranthus_cruentus	AcruScioBoG_3895_HRSCAF_39120195170.6
AcruScioBoG_3895_HRSCAF_39120195170.8	amaranthus_cruentus	AcruScioBoG_3895_HRSCAF_39120195170.8
AcruScioBoG_4088_HRSCAF_41070202770.1	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.1
AcruScioBoG_4088_HRSCAF_41070202770.11	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.11
AcruScioBoG_4088_HRSCAF_41070202770.12	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.12
AcruScioBoG_4088_HRSCAF_41070202770.2	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.2
AcruScioBoG_4088_HRSCAF_41070202770.3	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.3
AcruScioBoG_4088_HRSCAF_41070202770.5	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.5
AcruScioBoG_4088_HRSCAF_41070202770.6	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.6
AcruScioBoG_4088_HRSCAF_41070202770.7	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.7
AcruScioBoG_4088_HRSCAF_41070202770.9	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202770.9
AcruScioBoG_4088_HRSCAF_41070202840.1	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070202840.1
AcruScioBoG_4088_HRSCAF_41070204350.1	amaranthus_cruentus	AcruScioBoG_4088_HRSCAF_41070204350.1