Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT1638 SQE185 CAS2570

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT31757 SMO1/SMO21119 CPI1170 CYP51G1313 FK164 HYD1184 DWF71136 DWF5419 DWF1227

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET2416 DWF4/CYP90B1314 CPD/CYP90A1201 ROT3/CYP90C173 CYP90D11 BR6OX1/CYP85A131 BR6OX2/CYP85A27

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Bryophytes (9925)

Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Anthoceros agrestis Oxford

Funaria hygrometrica

Buxbaumia aphylla

Anthoceros punctatus

Calliergon cordifolium

Archidium alternifolium

Lineage Summary

Module Gene List

Gene	Species	Protein ID
Fhygscaffold_80348660	funaria_hygrometrica	Fhygscaffold_80348660
Fhygscaffold_80349620	funaria_hygrometrica	Fhygscaffold_80349620
Fhygscaffold_80358280	funaria_hygrometrica	Fhygscaffold_80358280
Fhygscaffold_90362110	funaria_hygrometrica	Fhygscaffold_90362110
Fhygscaffold_90362380	funaria_hygrometrica	Fhygscaffold_90362380
Fhygscaffold_90365300	funaria_hygrometrica	Fhygscaffold_90365300
Fhygscaffold_90368180	funaria_hygrometrica	Fhygscaffold_90368180
Gackstroemia3716390003900	gackstroemia	Gackstroemia3716390003900
Gackstroemia3869790009350	gackstroemia	Gackstroemia3869790009350
Gackstroemia3929850011640	gackstroemia	Gackstroemia3929850011640
Gackstroemia4329900020690	gackstroemia	Gackstroemia4329900020690
Gackstroemia4336320021350	gackstroemia	Gackstroemia4336320021350
Gackstroemia4458960025980	gackstroemia	Gackstroemia4458960025980
Gackstroemia4846980034540	gackstroemia	Gackstroemia4846980034540
Gackstroemia4996100043090	gackstroemia	Gackstroemia4996100043090
Gackstroemia5027580044670	gackstroemia	Gackstroemia5027580044670
Gackstroemia5346240050750	gackstroemia	Gackstroemia5346240050750
Gackstroemia5659210073780	gackstroemia	Gackstroemia5659210073780
Gackstroemia5668030074460	gackstroemia	Gackstroemia5668030074460
Gackstroemia5755600077710	gackstroemia	Gackstroemia5755600077710
Gackstroemia5775260080030	gackstroemia	Gackstroemia5775260080030
Gackstroemia5853160091320	gackstroemia	Gackstroemia5853160091320
Gackstroemia5902650095980	gackstroemia	Gackstroemia5902650095980
Gackstroemia5940970102440	gackstroemia	Gackstroemia5940970102440
Gackstroemia5950990105400	gackstroemia	Gackstroemia5950990105400
Gackstroemia5961540108030	gackstroemia	Gackstroemia5961540108030
Gackstroemia5990820113200	gackstroemia	Gackstroemia5990820113200
Gackstroemia6056450129890	gackstroemia	Gackstroemia6056450129890
Gackstroemia6090800142390	gackstroemia	Gackstroemia6090800142390
Gackstroemia6094940144260	gackstroemia	Gackstroemia6094940144260