Rosmarinic acid portable pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route

Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.

7 curated steps/modules

Phenylalanine Donor Branch

Substrate

L-Phenylalanine

C₉H₁₁NO₂

C₆H₅-CH₂-CH(NH₂)-COOH

Deamination into the phenylpropanoid donor branch

PAL7015

Product

trans-Cinnamic acid

C₉H₈O₂

C₆H₅-CH=CH-COOH

PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.

Substrate

trans-Cinnamic acid

C₉H₈O₂

C₆H₅-CH=CH-COOH

Cinnamate 4-hydroxylation

C4H48992

Product

4-Coumaric acid

C₉H₈O₃

4-HO-C₆H₄-CH=CH-COOH

C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.

Substrate

4-Coumaric acid

C₉H₈O₃

4-HO-C₆H₄-CH=CH-COOH

Substrate

CoA

C₂₁H₃₆N₇O₁₆P₃S

CoA-SH

CoA ligation to form the RAS acyl donor

4CL25914

Product

4-Coumaroyl-CoA

C₃₀H₃₈N₇O₁₈P₃S

4-HO-C₆H₄-CH=CH-C(=O)-SCoA

4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.

Tyrosine Acceptor Branch And Condensation

Substrate

L-Tyrosine

C₉H₁₁NO₃

4-HO-C₆H₄-CH₂-CH(NH₂)-COOH

Transamination to 4-hydroxyphenylpyruvate

TAT14219

Product

4-Hydroxyphenylpyruvate

C₉H₈O₄

4-HO-C₆H₄-CH₂-C(=O)-COOH

TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.

Substrate

4-Hydroxyphenylpyruvate

C₉H₈O₄

4-HO-C₆H₄-CH₂-C(=O)-COOH

Reduction to the HPLA acceptor

HPPR5065

Product

4-Hydroxyphenyllactate

C₉H₁₀O₄

4-HO-C₆H₄-CH₂-CH(OH)-COOH

HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.

Substrate

4-Coumaroyl-CoA

C₃₀H₃₈N₇O₁₈P₃S

4-HO-C₆H₄-CH=CH-C(=O)-SCoA

Substrate

4-Hydroxyphenyllactate

C₉H₁₀O₄

4-HO-C₆H₄-CH₂-CH(OH)-COOH

Ester-forming condensation

RAS13433

Product

4-Coumaroyl-4'-hydroxyphenyllactate

C₁₈H₁₆O₇

4-HO-C₆H₄-CH=CH-C(=O)-O-CH(COOH)-CH₂-Ar-OH

RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.

Substrate

4-Coumaroyl-4'-hydroxyphenyllactate

C₁₈H₁₆O₇

mono-catechol ester precursor

CYP98A14-type hydroxylation with CPR electron-transfer support

CPR5870

Product

Rosmarinic acid

C₁₈H₁₆O₈

caffeoyl-O-3,4-dihydroxyphenyllactate

CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Algae (388) Bryophytes (9418) Lycophytes/Ferns (423) Gymnosperms (1285) Basal angiosperms (2118) Monocots (23710) Eudicots (83094)

Species Distribution

Lineage Summary

Module Gene List

Gene	Species	Protein ID
aconitum_vilmorinianum_GWHPBRAL019070	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019070
aconitum_vilmorinianum_GWHPBRAL019160	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019160
aconitum_vilmorinianum_GWHPBRAL019243	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019243
aconitum_vilmorinianum_GWHPBRAL019277	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019277
aconitum_vilmorinianum_GWHPBRAL019278	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019278
aconitum_vilmorinianum_GWHPBRAL019655	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019655
aconitum_vilmorinianum_GWHPBRAL019661	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019661
aconitum_vilmorinianum_GWHPBRAL019662	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019662
aconitum_vilmorinianum_GWHPBRAL019985	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL019985
aconitum_vilmorinianum_GWHPBRAL020007	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020007
aconitum_vilmorinianum_GWHPBRAL020024	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020024
aconitum_vilmorinianum_GWHPBRAL020191	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020191
aconitum_vilmorinianum_GWHPBRAL020192	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020192
aconitum_vilmorinianum_GWHPBRAL020193	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020193
aconitum_vilmorinianum_GWHPBRAL020194	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020194
aconitum_vilmorinianum_GWHPBRAL020201	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020201
aconitum_vilmorinianum_GWHPBRAL020202	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020202
aconitum_vilmorinianum_GWHPBRAL020203	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020203
aconitum_vilmorinianum_GWHPBRAL020205	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020205
aconitum_vilmorinianum_GWHPBRAL020210	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020210
aconitum_vilmorinianum_GWHPBRAL020480	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020480
aconitum_vilmorinianum_GWHPBRAL020513	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020513
aconitum_vilmorinianum_GWHPBRAL020515	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020515
aconitum_vilmorinianum_GWHPBRAL020516	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020516
aconitum_vilmorinianum_GWHPBRAL020517	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020517
aconitum_vilmorinianum_GWHPBRAL020518	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020518
aconitum_vilmorinianum_GWHPBRAL020582	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020582
aconitum_vilmorinianum_GWHPBRAL020691	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020691
aconitum_vilmorinianum_GWHPBRAL020692	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020692
aconitum_vilmorinianum_GWHPBRAL020950	aconitum_vilmorinianum	aconitum_vilmorinianum_GWHPBRAL020950